HER3 expression was almost completely abrogated in BxPC3 cells after 2 hr of co-incubation (Figure 1A) and in DU145 cells after only 30 min (Figure 1B); such antibody-induced HER3 degradation being confirmed in MDA-MB468 triple-negative breast cancer (Supplementary Figure S2). The gene discussed is ERBB3; the disease is triple-negative breast carcinoma.