To identify whether the hypergeneration of ROS by silencing GLRX3 in NPC cell lines contributes to inhibiting the Akt signaling cascade, we decreased the ROS level in shGLRX3-HONE1/CNE2 cells by an ROS inhibitor N-acetyl cysteine (NAC) (Figure 6D, 6E). This evidence concerns the gene GLRX3 and nasopharyngeal carcinoma.