We found that knockdown of GLRX3 in NPC cells significantly downregulated EGFR expression at both the mRNA and protein levels, whereas EGF could slightly increase the pAkt level, which suggests that loss of EGFR expression accounts for lowering pAkt and suppressing cell proliferation, colony formation and metastasis capacity. The gene discussed is GLRX3; the disease is nasopharyngeal carcinoma.