As a result, the objective of this present study was to assess the feasibility of the intra-arterial (IA) route in successfully delivering human umbilical cord blood-derived MSCs (hUCB-MSCs) into the brains of non-transgenic WT (C3H/C57) and transgenic AD (APP/PS1) and to provide the grounds for clinical advancement of this delivery route for stem cell therapy of AD patients. The gene discussed is PSEN1; the disease is Alzheimer disease.