To the best of our knowledge, this is the first paper investigating on the delivery of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) into the brains of transgenic AD (APP/PS1) and non-transgenic WT (C3H/C57) mice following administration through the intra-arterial (IA) route. Here, PSEN1 is linked to Alzheimer disease.