To further investigate whether sorafenib inhibits macrophage-induced EMT and migration of hepatocellular carcinoma cells via the HGF-Met signaling pathway, we used real-time PCR to examine mRNA expression of HGF receptor Met and the TGF-β receptor TGFBR2 in HepG2 and HL7702 cells cultured with the supernatant from polarized macrophages. Here, TGFBR2 is linked to hepatocellular carcinoma.