The Km of CYP2C8 was higher (25.7 vs. 21.4 μM; P < 0.05), but the value of CYP2D6 was lower (21.4 vs. 41.9 μM; P < 0.01) in the cirrhosis group relative to the fibrosis group, respectively. Here, CYP2C8 is linked to Cirrhosis.