CYP2D6 and Cirrhosis: The presence of cirrhosis significantly affected CYP2D6 activity by causing a decrease in the Km value (21.4 vs. 28.9μM, respectively; P < 0.05) and an increase in the CLint value (8.4 vs. 3.5 μl/min/mg, respectively; P < 0.01) relative to controls.