Several previous studies reported that the activities of several CYPs, including CYP1A2, CYP2A6, CYP2D6, CYP2C19, CYP2E1, and CYP3A were decreased in cirrhosis patients relative to healthy subjects [15, 16, 19-21, 31-35]. The gene discussed is CYP2C19; the disease is Cirrhosis.