In terms of Vmax, CYP2A6, CYP2B6, CYP2C9, CYP2D6, CYP2E1, and CYP3A4/5 were increased, while the Vmax values of CYP1A2 and CYP2C8 were decreased in both the cirrhosis and fibrosis groups compared to control subjects. This evidence concerns the gene CYP2E1 and fibrosis.