CYP3A4 and fibrosis: In terms of Vmax, CYP2A6, CYP2B6, CYP2C9, CYP2D6, CYP2E1, and CYP3A4/5 were increased, while the Vmax values of CYP1A2 and CYP2C8 were decreased in both the cirrhosis and fibrosis groups compared to control subjects.