What remain unclear are the mechanisms of CYP1A1 regulation of BCL2. Expression of BCL2 is involved in the PI3K-AKT signaling pathway implicated in the development and progression of prostate cancer [45–47] and indeed, CYP1A1 metabolites have been shown to lead to AKT phosphorylation [48]. This evidence concerns the gene AKT1 and prostate carcinoma.