Nevertheless, some contradictory results need attention, with one study demonstrating the high PKM2 expression in poorly differentiated esophageal squamous cell cancer tissues [38], another showing that PKM2 promotes OCT4 expression in hypoxic hESCs and also enhances its transcriptional activity by binding to OCT4 [42]. The gene discussed is POU5F1; the disease is esophageal squamous cell carcinoma.