However, the specific binding of the H103 scFv Ab to hypoxic cells (Figures 2C, 2D, 3B, 4A, 4C; Table S2) and its antigen PKM2 identification based on cell surface-biotinylation (Figure 5) in this study, both support that a fraction of PKM2 protein did present on the hypoxic liver cancer cell surface. Here, PKM is linked to liver cancer.