IFN-γ is a pleiotropic cytokine whose biological role has been extensibly associated with pro-cytotastic and pro-apoptotic effects against several malignancies.[33] This powerful cytokine up-regulates MHC-I molecule expression on tumor cells, increasing tumor antigen presentation,[34, 35] and participates in the recruitment and activation of several immune cells.[36] Concomitantly, these T cells primed by desialylated MoDCs exhibited the highest cytotoxic activity against tumor cells. Here, IFNG is linked to neoplasm.