According to the tumor types, the reduced time periods of recurrence-free survival were observed in adenocarcinoma patients with GLK-High (n = 38, GLK-High versus GLK-Low, P = 0.035) but not in squamous cell carcinoma patients with GLK-High (n = 20, GLK-High versus GLK-Low, P = 0.245; Supplementary Figure S5B). This evidence concerns the gene GCK and squamous cell carcinoma.