CGA and B-cell chronic lymphocytic leukemia: To this aim we have analyzed the levels of CgA and VS-1 in the plasma of CLL patients, and investigated their effects on CLL progression in Eμ-TCL1 mice, a transgenic model of CLL [22] and in Rag2−/−γc−/− mice engrafted with human MEC1 CLL cells, a xenograft model [23].