SMO and melanoma: Further analysis of this putative target list identified 18 genes that are associated with growth and/or metastatic processes (Supplementary Table S5), and of these 10 (CTSK, IRS2, PAK1, POLE4, RAF1, RELA, SMO, SP1, STMN3, TGFA) have been previously implicated in melanoma, thus representing a pro-metastatic gene signature that is repressed by miR-7-5p (Figure 3C).