A study by Ning et al. identified loss of expression of the transcription factor Hepatocyte Nuclear Factor 4α (HNF4α) as mediating reduced miR-7-5p levels in metastatic hepatocellular carcinoma, and showed that ectopic expression of HNF4α reduced NF-κB activity and inhibited tumor cell migration, invasion and lung metastasis [39]. The gene discussed is HNF4A; the disease is neoplasm.