Data on survival and mRNA expression for 463 melanoma patients was analyzed by Cox regression, and after adjustment for age and sex, high expression of RelA (hazard ratio (HR) = 1.55, p-value = 0.007; Figure 4B), POLE4 (HR = 1.45, p-value = 0.023) and SP1 (HR = 1.40, p-value = 0.032) was predictive of poorer overall survival (Table 1). The gene discussed is POLE4; the disease is melanoma.