TPO and hypothyroidism: All patients with TSH ≥10 mIU/L, or clinical features of hypothyroidism, should be treated.10,11 In patients with subclinical hypothyroidism and TSH <10 mIU/L, treatment should be considered with goiter, infertility, and high anti-TPO antibodies.10 Treatment of patients with anti-TPO Abs and TSH between 3 and 5 mIU/L is still controversial, though consensus can be made that these patients should be followed-up closely, almost every 6 to 12 months to monitor rise in TSH and hypothyroid symptoms.