Interestingly, LPA/PKD-1 signaling suppresses CD36 transcription and reprograms MVECs for arteriogenic gene expression via a nuclear HDAC7-FoxO1 complex, implicating microvascular remodeling and tumor arteriogenesis (Kohlenberg et al., 2013; Ren et al., 2015). The gene discussed is FOXO1; the disease is neoplasm.