With this method, there was a statistically significant improvement in LC among metastases with mutated BRAF. At 1 year, LC was 34 vs. 69% [RR = 0.3 (95% CI 0.1–0.7, p = 0.01)] for BRAF wild-type vs. BRAF mutant metastases, respectively (Figure 1B). This evidence concerns the gene BRAF and laryngotracheoesophageal cleft.