Eliaz and Szoka [125] demonstrated that doxorubicin (DOX) encapsulated in HA-conjugated liposomes was significantly more potent to CD44-overexpressing cells (B16F10, murine melanoma cell line) compared with free DOX and significantly less toxic than the free DOX to CD44-low expressing cells (CV-1, African green monkey kidney cells). This evidence concerns the gene CD44 and melanoma.