Clinical data demonstrate that both hyal1 and hyal2 genes are overexpressed in advanced stages of colorectal disease [104]. In vitro knockdown of hyal1 gene expression in breast cancer cells (MCF7 and ZR-75-30 cells) showed reduced cell growth, adhesion, invasion, and angiogenesis, while induced overexpression of the isoenzyme elevated cell malignancy. The gene discussed is HYAL1; the disease is breast cancer.