Furthermore difference in expression have can also be modulated by gestational age, with the transcript levels of the PHLDA2 gene showing an association with birth weight (although not IUGR) in term samples (Apostolidou et al., 2007; Ishida et al., 2012) but not in first trimester chorionic villus sampling (Demetriou et al., 2014). Here, PHLDA2 is linked to fetal growth restriction.