However, in addition to its antitumor activities, cellular-targeted long DLI HY-PDT induced the expression of some angiogenic proteins in tumor tissue, including VEGF, tumor necrosis growth factor-α (TNF-α) and interferon-α (INF-α), which potentially lead to the formation of new vessels (Bhuvaneswari et al., 2008). The gene discussed is VEGFA; the disease is neoplasm.