More importantly, Treg-specific EZH2 deletion renders Tregs phenotypically normal and functional in vitro but unable to properly maintain immune homeostasis in vivo, as supported by the fact that Treg.EZH2Δ/Δ mice presented numerous signs of autoimmunity, including weight and hairy loss and scaly tails (33). The gene discussed is EZH2; the disease is Autoimmunity.