On the one hand, Hsp70 either alone or in combination with immunogenic peptides is able to induce the maturation of dendritic cells (DCs), activate the cytolytic, proliferative, and migratory capacity of NK cells, stimulate the antigen-dependent T cell activation and IFN-γ secretion, induce the release of pro- and anti-inflammatory cytokines, on the other hand, membrane-bound Hsp70 acts as a tumor-specific antigen, which is recognized by preactivated NK cells. The gene discussed is IFNG; the disease is neoplasm.