Between 2000 and 2014, gp96 and HSP70–peptide-based vaccines derived from autologous tumor lysates were clinically applied in phase I to phase III clinical trials in different tumor entities including late stage melanoma (42) either alone or in combination with GM-CSF and IFN-γ (43–48), metastatic colon carcinoma (49), renal cell carcinoma (50), gastric carcinoma (51, 52), pancreatic carcinoma (53), chronic myeloid leukemia (54), and glioblastoma (55) (Table 1). This evidence concerns the gene HSPA1A and glioblastoma.