Although this review focuses on cytokines efficiently targeting hepatocytes, it is important to note that modulation of murine APAP-induced ALI by endogenous IL-10 (and IL-13) unequivocally indicate a pivotal function of STAT3 also in myeloid cells (monocytes/macrophages/Kupffer cells) for determining course and outcome of APAP intoxication. The gene discussed is IL10; the disease is acute respiratory distress syndrome.