Here, we computationally design and in silico assess both consensus and mosaic MOMP antigens for broad T-cell coverage against the C. trachomatis genital serovars D–K, for the reasons that (a) chlamydial infections in both animal models and humans suggest a strong protective role for CD4+ Th1-biased immune responses (4, 13, 14) and (b) that these may be supplemented by MOMP-specific antibodies able to mediate antibody-dependent cellular cytotoxicity (ADCC) (15). The gene discussed is CD4; the disease is chlamydia trachomatis infectious disease.