CRH and Anxiety: Overlapping anti-reward anxiety-inducing neuroadaptations in the extended amygdala’s neural network [e.g., amplifying pathophysiological noradrenaline signaling, and interconnected corticotrophin-releasing factor/hormone (CRF/CRH) and dynorphin-mediated signaling] after repeated pain or opioid use and during opioid withdrawal may drive common maladaptive negative emotional responses to stress.