Hasler et al. (193), and more recently, Goldstein and Klein (194) have published detailed reviews about both psychopathological (e.g., neuroticism, anhedonia, depressed mood, increased stress sensitivity), and biological (e.g., morning cortisol, tryptophan depletion, DEX/CRH, CRH dysfunction, hippocampal volume, and reduced 5HT1A receptor expression) endophenotypes for depression. The gene discussed is CRH; the disease is major depressive disorder.