ATP1A2 and amyotrophic lateral sclerosis: While most neurological studies involving the α2 subunit focus on its effect in FHM2, several recent studies have also linked the Na+/K+-ATPase to other critical neurological disorders such as Amyotrophic lateral sclerosis (ALS), Huntington's disease and Alzheimer's disease (Acuña et al., 2013; Valencia et al., 2013; Gallardo et al., 2014; Ohnishi et al., 2015).