Several pro-inflammatory cytokines (IL-1β, TNFα, IL-6, and TGFβ) and inflammatory mediators (CGRP) are increased in the DRG in response to bone cancer and fracture (Kon et al., 2001; Cho et al., 2002; Kang et al., 2005; Rundle et al., 2006; Baamonde et al., 2007; Geis et al., 2010; Fang et al., 2015; Hansen et al., 2016). Here, IL1B is linked to bone neoplasm.