The dramatic effects elicited by the Aβs excess due to such mutations have inspired the “amyloid cascade hypothesis” of AD which posits that Aβ-os precede the manifestation of toxic hyperphosphorylated (p)-Tau proteins and neurofibrillary tangles (NFTs) (Hardy and Selkoe, 2002; Selkoe, 2008a,b). Here, MAPT is linked to Alzheimer disease.