DDX41 and Alzheimer disease: Synaptically disconnected and deceasing neurons stuffed up with Aβs and NFTs appear first in the LEC allocortex and subiculum/CA1 areas (Braak and Braak, 1991a; Gómez-Isla et al., 1996; Khan et al., 2014) and later spread slowly to the parietal lobes and other cognition-related cortical areas of human AD brains (reviewed in Dal Prà et al., 2015a; Figure 1A).