We found that, when starting Vinflunine, 10% of our patients had a PS ≥ 2; 40% had a Creatinine Clearance < 60 ml/min (5% < 40 ml/min); 60% had lung or liver metastases; 12% had grade 2 anemia (Hemoglobin, Hb, < 10 mg/dl). Here, GSTM1 is linked to anemia.