APP and Dravet syndrome: Accordingly, the overexpression of specific genes located in the long arm of Hsa21, such as DS Critical Region 1 (DSCR1), the Amyloid-beta Precursor Protein (APP) and the dual-specificity tyrosine (Y)-phosphorylation regulated kinase 1A (DYRK1A) genes have been reported in DS patients (Antonarakis et al., 2004; Shukkur et al., 2006).