Although the exact causes of AD are still much discussed, the pathology is characterized by the presence of intra- and extracellular protein aggregates mainly composed of Tau and β-amyloid (Aβ) proteins, which are toxic to the brain since they induce the loss of synapses, synaptic impairments and consequently, neuronal cell death (reviewed in Spires-Jones and Hyman, 2014). This evidence concerns the gene MAPT and Alzheimer disease.