Tumor-derived EVs can induce T cell apoptosis via FasL (Andreola et al., 2002; Huber et al., 2005) and galectin-9 (Klibi et al., 2009), inhibit IL-2-induced T cell proliferation (Thery et al., 2002), promote Tregs (Szajnik et al., 2010), reduce CD8+ T cells proliferation (Wieckowski et al., 2009) and decrease NK cell cytotoxicity (Ashiru et al., 2010), as well as induce myeloid supressor cells (Cocucci et al., 2007). This evidence concerns the gene CD8A and neoplasm.