CD8A and neoplasm: Cancer EVs can stimulate the immune response by transferring tumor antigens to DCs (Wolfers et al., 2001), leading to Ag-specific T cell activation, in particular of CD8 cytotoxic T lymphocytes (CTL) clones (Hsu et al., 2003; Utsugi-Kobukai et al., 2003; Chaput et al., 2004; Escudier et al., 2005).