HTRA1 and age-related macular degeneration: Analysis of far more samples and correlation with precise diagnosis and ideally, genetic screening of genes strongly associated with AMD, e.g., CFH (Boon et al., 2009), ARMS2 (Fritsche et al., 2008; Friedrich et al., 2011) and HTRA1 (Dewan et al., 2006) as well as seven new loci associated with AMD (Fritsche et al., 2013) would be required to definitively identify whether tiling in the RPE is a normal finding of aging, or if it is associated with AMD.