To explore this possibility, we quantified TRAIL- and ibrutinib-induced apoptosis in a mostly independent cohort of six CLL samples with del(8p) and in nine non-del(8p) controls (del(8p) status verified with FISH (Fig. 5a–c and Supplementary Fig. 5D) from patients not previously treated with ibrutinib. Here, TNFSF10 is linked to B-cell chronic lymphocytic leukemia.