TP53 and cancer: The pre-FCR leukaemic population was composed predominantly of a clone harbouring a mutation in SF3B1 (pG742D), which was eradicated by FCR therapy, and replaced with a clone harbouring biallelic inactivation of TP53, trisomy 12 and a new mutation in SF3B1 (p.K666T; cancer cell fraction (CCF) of 74%).