MYC and cancer: Given the known deregulation of cancer epigenomes due to mis-expression or mutation of epigenetic factors [32, 33], the de-regulation of CRMs in the BJ system, and the fact that c-MYC recruits a variety of epigenetic factors and chromatin remodelers to its targets [34, 35], we performed a genome-wide analysis of chromatin state transitions for all three steps of the cell transformation.