SMAD7 and cancer: Several functionally related (GO term 45595: regulation of cell differentiation) TFs, such as MYOCD, TWIST1, TBX5, and SMAD7, which are known to be involved in cancer development and/or sustainment [25–27], are specifically associated regulators of genes that are down-regulated along the cell transformation process in our model system (pathways v, vi, and vii).