In addition, Poly(I:C) inhibition of tumor-induced Chi3l1 was also dependent on IFNAR1 (Fig. 4c) and the ability of Poly(I:C)-induced RLH activation to inhibit melanoma metastasis was significantly decreased in mice with null mutations of IFNAR1 (Fig. 4d,e). This evidence concerns the gene IFNAR1 and neoplasm.