Specifically they demonstrate that the inhibition of melanoma metastasis that is caused by Poly(I:C)-induced RLH activation is associated with impressive increase in chemerin and NK cell, but not CD8+ or CD4+ T cell or CD19+ B cells, accumulation and that both are mediated by a MAVS- and Chi3l1-dependent mechanism(s). This evidence concerns the gene RARRES2 and melanoma.