LAG-3 expression in CD4+2D2-IEL-THIGH cells from the gut was minimal, but its intracellular expression was markedly higher in the CNS-CD4+2D2-IEL-THIGH cells (Fig. 5c), similar to what was previously reported in tumour-infiltrating CD8+ T cells23. The gene discussed is CD4; the disease is neoplasm.