In our previous study, we presented that BV suppressed cancer cell growth via activation of DR3 in NSCLC cells10, Myriocin induced apoptotic cell death through activation of DR4 in NSCLC cells25, (E)-2,4-bis (p-hydroxyphenyl)-2-butenal showed anti-cancer effect via activation of DR5 in NSCLC cells12. This evidence concerns the gene TNFRSF25 and cancer.