This lack of protective effect was associated with the loss of coupling between ORs and glycogen synthase kinase 3β (GSK‐3β).290 It was also shown that remifentanil reduced myocardial infarct size and prevented apoptosis of cardiomyocytes evoked by I/R in nondiabetic rats but not in rats with streptozotocin‐induced diabetes.89 Gross's group's data were confirmed by Chen et al.199 They demonstrated that sufentanil reduced myocardial infarct size in the nondiabetic rats, but not those with streptozotocin‐induced diabetes. The gene discussed is GSK3B; the disease is myocardial infarction.