PTGS1 and infection: Several genes involved in arachidonic acids metabolism, including eicosanoids metabolism, were significantly impacted by infection, such as arachidonate 5-lipoxygenase (ALOX5) and its activating protein (ALOX5P), prostaglandin reductase 1 (PTGR1), prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (PTGS1, COX1), and thromboxane A synthase 1 (TBXAS1), were all strongly upregulated by infection in CHB.