TSPAN7 and Intellectual disability: For instance, TCONS_ 00132850 and TCONS_00132849 are brain-specific HQ transcripts divergently expressed from Tspan7. The gene Tspan7 encodes for Tetraspanin 7, a transmembrane protein associated to X-linked mental retardation (Supplemental Fig. S19A; Holinski-Feder et al. 1999; Zemni et al. 2000; Abidi et al. 2002; Maranduba et al. 2004).