We confirmed here that pre‐treatment of HS5 with LAMA84 exosomes increases the adhesion of leukaemic cells to the stromal monolayer; moreover, the treatment with gefitinib reverts these effects, confirming a possible role of EGFR in regulating leukaemic cells adhesion inside the tumour microenvironment of CML. The gene discussed is EGFR; the disease is neoplasm.