To confirm the presence of EGFR ligands also in vivo, we collected blood samples from 13 newly diagnosed CML patients and extracted RNAs; the real‐time PCR showed that CML patients expressed mRNA of HBEGF, EREG and AREG (Fig. 1B and Fig. S2A and B). This evidence concerns the gene EGFR and chronic myelogenous leukemia, BCR-ABL1 positive.