Autoreactive T-cells can result in inflammatory demyelination of the CNS, and knowing that the frequency of Tregs in MS patients is unchanged from controls [27] (although their function is impaired) could be a clue to the decreased demyelination seen only in Ast-IL-6 KO females, the only group that presented a decrease in T lymphocyte infiltration. This evidence concerns the gene IL6 and myeloid sarcoma.