FZD7 is upregulated in human glioblastoma stem cells, and whilst no experiments have yet been performed to specifically address the role of FZD7 in these cells, overexpression of sFRP1 halts cell cycle and induces apoptosis, suggesting the Wnt receptor complex, and possibly FZD7, are attractive targets to treat glioblastoma [227,228]. The gene discussed is FZD5; the disease is glioblastoma.