WNT5A and gastric cancer: Wnt5a, which primarily activates the non-canonical pathway, is up-regulated in human gastric tumours, however, this is not observed in cultured human GC cell lines (OKAJIMA, TMK1, MKN7, MKN28, MKN74 and KATOIII) suggesting the source of Wnt5a is from stromal cells [182].