Subsequent studies demonstrated that Apc is a potent tumour suppressor; a mutagenesis screen in mice identified that mutation to Apc caused multiple intestinal adenoma’s (these mice were called ApcMin/+) [75,145], whilst conditional truncation of Apc throughout the intestine using transgenic mice resulted in rapid uncontrolled proliferation similar to tumourigenesis [146,147]. This evidence concerns the gene APC and neoplasm.