FZD7 and hepatocellular carcinoma: For instance, HCC cell lines (HepG2 and Huh7) treated with a recombinant soluble FZD7 (sFZD7) peptide, which contains the extracellular domain of FZD7, inhibits Wnt/β-catenin signalling and decreases cell proliferation and viability (without effecting normal hepatocytes) [170].