Although the role of FZD7 has not been described in all cancers with high Wnt activity it is tempting to speculate that FZD7 may be involved in these cancers also, particularly as it is a Wnt target gene [87,88], and it will be interesting in future studies to examine to full extent to which FZD7 is required in the following cancers. The gene discussed is FZD7; the disease is cancer.