Thus, induction of genes involved in cell death by 177Lu-trastuzumab treatment appears independent of p53. p73 is one of the p53 tumor suppressor family and is involved in cell cycle arrest and induction of cell death due to DNA damage and there are tumors that lack a functional p53 that do then functionally express p73 [29,30,31,32]. This evidence concerns the gene TP53 and neoplasm.