BACE1 and Alzheimer disease: In a previous work, the benzophenone 1, bearing a N,N’-benzylmethylamine moiety, was selected as the main scaffold to be optimized, allowing us to obtain a mutitarget AD-drug candidate able to efficiently inhibit BACE-1 enzyme (low-micromolar potency) and to offer protection against Aβ-induced neurotoxicity as well [18].