Over 90 substrates have been identified so far including amyloid precursor protein (APP), Notch and Eph receptors and ligands, cadherins, and deleted in colorectal cancer (DCC) (Haapasalo and Kovacs, 2011; Kopan and Ilagan, 2004; McCarthy et al., 2009; Parks and Curtis, 2007). The gene discussed is APP; the disease is cancer.