In agreement with its effect on the sensitivity of the cancer cells to ABT-888, salubrinal mimicked the effect of vorinostat on increased phosphorylation of eIF2α in ABT-888 treated cells and similar to the combination of vorinostat and ABT-888, the combination of salubrinal and ABT-888 did not reduce the level of RAD51. The gene discussed is RAD51; the disease is cancer.