Of note, in untreated fibroblasts or normal breast cells, the level of total eIF2α was much lower and the level of the phosphorylated protein was much higher than in the untreated human breast cancer cell line MDA-MB-231 (Fig 3e), suggesting that normal cells may be more tolerant than cancer cells to increased phosphorylation of eIF2α. The gene discussed is EIF2A; the disease is breast cancer.