Interestingly, IDH2‐mutated cells were shown not to exhibit the same alteration in the hypoxia‐mediated mitochondrial metabolic phenotype.117 These data may shed more light on the metabolic differences induced by IDH1 and IDH2 mutations and therefore their different prevalence in glioma—a highly hypoxic type of tumor. The gene discussed is IDH1; the disease is central nervous system cancer.