Given that the cytosolic pathway has been shown to be important in hypoxic reductive carboxylation for lipogenesis,30, 32, 33, 34 and that gliomas appear to ‘favor’ IDH1 mutations, there may be a requirement for IDH2 wild‐type activity in hypoxic IDH1 mutant gliomas. The gene discussed is IDH2; the disease is central nervous system cancer.