However, the expression of Pkd2, Pkhd1, Kif12, Cadherin16 and Socs3, which are known as HNF-1β target genes, did not change (data not shown), and only a few genes, including NR1H4, MITF, SLC3A1, and SLCO4C1, were significantly upregulated 9 h after Ad-HNF1B infection. The gene discussed is SOCS3; the disease is infection.