Lymph node metastasis was detected in 23 patients (8.8%) of TME group, 7.3% (13 in 176 patients) in ypT0, 4.8% (1 in 21 patients) in ypTis, and 14.1% (9 in 64 patients) in ypT1. The gene discussed is RAB1A; the disease is metastatic malignant neoplasm in the lymph nodes.