According to Mente et al, there is a positive link between leptin levels and obesity and insulin resistence.47 It is already well-known that there is an opposite relation of adipokines with fat mass, a direct relation of leptin, and a reverse relation of adiponectin, respectively.48 Our results show higher leptin levels in obese children; these increase being significant in normal allele carriers irrespective of FTO SNP. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.