In some results from the literature, the leptin/adiponectin ratio express a more intrinsic role in related inflammatory process on obesity than these hormone observed alone in its concentrations.47–51 In our research, we found a significant correlation of leptin/adiponectin ratio just with BMI only in FTO rs9939609 AT genotype. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.