MTHFR and hyperhomocysteinemia: The studies have shown that intake of folate above 310 μg/day may protect against the risk of gastric cancer.52 Folate consumption may interact with MTHFR C677T polymorphism to play a role in blood homocysteine levels with gastric cancer risk, just like previous studies of the effect of folate supplement on carcinogenesis.27,31 Epidemiological studies have found MTHFR c.677C > T homozygosity with lifelong associate hyperhomocysteinemia with increased risk of GC.10 Research studies show a relationship among low levels of folic acid, vitamin B12, high homocysteine levels, and GC.